Key features and details | |
Cat. No. | MABL-867 |
Name | Anti-CD3 epsilon mAbs |
Clone No. | AFD- 12F6 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Activate, FC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds to human CD3. |
Alternative Name | Leu4/T3; ET-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e |
UniProt | P07766 |
Immunogen | Human CD3 |
Application Notes | This antibody competes for CD3 binding with the therapeutic antibody OKT3 (Ab00122). 12F6 binding to CD3 on human T-cells stimulates the secretion of TNF-alpha, INF-gamma and IL-10. Humanized versions of this antibody are also available. |
Antibody First Published | Wong & Colvin Bi-specific monoclonal antibodies: selective binding and complement fixation to cells that express two different surface antigens. J Immunol. 1987 Aug 15;139(4):1369-74. PMID:3112233 |
Note on publication | Describes generation of anti-CD3 antibody and further use in generation of bi- specific hybrid-hybridoma. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
