Key features and details | |
Cat. No. | MABL-881 |
Name | Anti-CD32 mAbs |
Clone No. | AFD- AT128 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | antagonist, WB, FC, IF, IHC |
Species Reactivity | Mouse |
Basic Information | |
Specificity | This antibody binds mouse IgG Fc receptor II beta (CD32 or Fc-gamma RIIb). CD32 is an Fc gamma surface receptor protein with a low affinity for IgG antibodies that expresses on B cells, monocytes/macrophages, NK cells, granulocytes, mast cells, and dendritic cells. CD32 binds antibody- antigen immune complexes and mediates adaptive immune responses. |
Alternative Name | Fc-gamma RII; Fc-gamma RII-b; Fc-gamma RIIB; FcγRIIb; FcγRII; FcRII; FcRII-b; FCGR2; Fcgr2b; Fc gamma receptor IIB; IgG Fc receptor II beta; Low affinity immunoglobulin gamma Fc region receptor II b; Lymphocyte antigen 17; Ly-17 |
UniProt | P08101 |
Immunogen | The original antibody was generated by immunization of BALB/c FcγRIIB−/− mice with FcγRIIB‒rat CD4 domain 3/4 fusion protein. |
Application Notes | |
Antibody First Published | Williams et al. Development and characterization of monoclonal antibodies specific for the murine inhibitory FcγRIIB (CD32B). Eur J Immunol. 2012 Aug;42(8)：2109-20. doi： 10.1002/eji.201142302. PMID：22760702 |
Note on publication | The original publication focuses on the development and characterization of monoclonal antibodies specific for murine inhibitory FcγRIIB (CD32B). |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
