Key features and details | |
Cat. No. | MABL-901 |
Name | Anti-CD37 mAbs |
Clone No. | AFD- IPO-24 (ZC37-24) |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | FC, IF, IHC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody recognizes CD37, which is a cell surface protein, present mostly on mature B cells and B cell malignancies. |
Alternative Name | Tetraspanin-26; Leukocyte antigen CD37; tetraspanin; Tspan-26; Gp52- 40 |
UniProt | P11049 |
Immunogen | This antibody was raised by immunizing mice with spleen cells of a patient with hairy cell leukemia. |
Application Notes | This antibody is recommended for the analysis and detection of B cells and their malignancies as CD37 is a valuable and stable marker for peripheral mature B-cells and corresponding malignancies, such as B-cell chronic lymphocytic leukemia (B-CLL), hairy cell leukemia (HCL), and all types of B-cell non-Hodgkin's lymphoma (B-NHL). Consequently, this antibody might be useful for the treatment of B cell malignancies and autoimmune and inflammatory diseases that involve B cells in their pathology. Finally, IPO-24 antibody, might be used to identify CD37 via various techniques. For instance, it was used to evaluate CD37 expression in mantle cell lymphoma samples via immunohistochemistry (Leshchenko et al., 2010). |
Antibody First Published | Moldenhauer CD37. J Biol Regul Homeost Agents. 2000 Oct-Dec;14(4):281-3. PMID:11215818 |
Note on publication | This article describes the characterization of the IPO-24 antibody. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
