Key features and details | |
Cat. No. | MABL-912 |
Name | Anti-CD38 mAbs |
Clone No. | AFD- OKT10 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | IP, FC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody recognizes and antigenic structure of 45,000 daltons type II transmembrane glycoprotein present on human precursor B cells and T cells, activated T cells, natural killer cells and some monocytes, myeloblasts and erythroblasts. It is also reported to strongly react with surface membrane of plasma cells. |
Alternative Name | T10; ADPRC 1; cADPr hydrolase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; Cyclic ADP-ribose hydrolase 1; CD31 ligand. |
UniProt | P28907 |
Immunogen | The original antibody was generated by immunizing CAF1 mice with human thymocytes. |
Application Notes | This antibody reacts with various lymphoid cell populations and thymocytes. OKT10 along with other antibodies was used to describe the stages of intrathymic development of human thymocytes. It was reported that all the thymocytes intially bear the OKT10 marker. As the thymocytes are exported to peripheral T-cel compartment they lose the OKT10 marker, as OKT10 could not react with peripheral T-cells (PMID:6966400). OKT10 is reported to bind to leukaemias and normal marrow cells of the myeloid and B cell lineages (PMID:6169674). OKT10 was used to study final B cell maturation since the OKT10 antigen is expressed on mature lymphocytes and lymphoplasmacytic cells. OKT10 reactivity is inversely proportional to the presence of Ia-like antigen expression. Therefore, these two antigens can be employed as complementary opposite reactants for the study of mature B cell malignancies, such as CLL, multiple myeloma, and Waldenström malignancy. (PMID:6813349). |
Antibody First Published | Reinherz et al. Discrete stages of human intrathymic differentiation:Analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage PNAS; Issue: 3; Volume: 77, Pages: 1588-1592. PMID:6966400 |
Note on publication | Describes the generation of antibody and its use with other antibodies to define the three discrete stages of human intrathymic T-cell differentiation. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
