Cat. No.
MABL-1700
Application
Block, FC
Isotype
Engineer antibody
Species Reactivity
Mouse
Clone No.
YGITR765
From
Recombinant Antibody
Specificity
This antibody binds murine GITR.
Alternative Names
CD357; Tumor necrosis factor receptor superfamily member 18; TNFRSF18; AITR; GITR-D; activation-inducible TNFR family receptor; AITR; glucocorticoid-induced tumor necrosis factor receptor
UniProt
Immunogen
nB2/6TG cells transfected with mouse GITR injected into DA rats.
Application Notes
A chimeric version of this antibody featuring a human IgG1 Fc-portion engineered to lack the N-linked glycosylation site at amino acid 297 was shown to enhance humoral immune responses by blocking GITR signallin (Ponte 2010).
Antibody First Published
Cobbold et al. Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants. J Immunol. 2004 May 15;172(10)：6003-10. PMID：15128783
Note on publication
Describes the use of this antibody in flow cytometry.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
