Key features and details | |
Cat. No. | MABL-915 |
Name | Anti-CD39 mAbs |
Clone No. | AFD- I-391 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | neutralize, ELISA, FC |
Species Reactivity | Human, Cynomolgus Monkey |
Basic Information | |
Specificity | This antibody recognizes and binds human and cynomolgus monkey CD39. NTPDase 1 (ectonucleoside triphosphate Di phosphohydrolase, also known as CD39/ENTPD1 or vascular CD39, functions together with another enzyme, CD73 (ecto-5'- nucleosidase), to hydrolyze extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to generate adenosine, which binds to adenosine receptors and inhibits T-cell and natural killer (NK)-cell responses, thereby suppressing the immune system. This protein could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet- activating ADP to AMP. |
Alternative Name | ENTPD1; NTPDase 1; Ectonucleoside triphosphate diphosphohydrolase 1; Ecto-ATP diphosphohydrolase 1; Ecto-ATPDase 1; Ecto-ATPase 1; Ecto-apyrase; Lymphoid cell activation antigen |
UniProt | P49961 |
Immunogen | |
Application Notes | The binding characterization of this antibody for CD39 expressed on Ramos cells was done using flow cytometry (WO2018065552). The binding of this antibody to various recombinant human CD39 isoforms was detected using ELISA. This antibody bound only vascular CD39, without any binding to CD39-L1, CD39-L2, CD39-L3 or CD39-L4. This antibody did not induce or increase CD39 down regulation. It was reported that this antibody is very potent at blocking CD39 enzymatic activity and is capable of neutralizing ATPase activity (US20190153113). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
