Cat. No.
MABL-1846
Application
FACS, in vivo, FC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
F17B1
From
Recombinant Antibody
Specificity
The antibody is specific for HLA class I. The antibody binds to the following subclasses: A2, A3, A11, A23, A24, A25, A26, A29, A30, A31, A32, A33, A34, A68.
Alternative Names
UniProt
Immunogen
The original antibody was generated by immunizing male MRL/lpr mice with an an emulsion containing complete adjuvant H37Ra and purified sHLA-A-flag protein.
Application Notes
The original antibody showed strong cell death-inducing activity by FACS analysis. The antibody was used for detection of beads coated HLA class I antigen by flow cytometry. The human chimeric and the humanized version of the antibody was constructed. The human chimeric antibody was administered into a mouse model for human myeloma. The result showed that the antibody can significantly prolong the survival period of the mouse model for human myeloma.
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
