Cat. No.
MABL-1908
Application
Blocking, WB, ELISA
Isotype
Engineer antibody
Species Reactivity
Rat, Human, Mouse
Clone No.
mAb 192
From
Recombinant Antibody
Specificity
The antibody binds to human muscle AChR with a Kd of 10 pM, to mouse muscle AChR with a Kd of 50 pM, and to rat muscle AChR with a Kd of 646 nM.
Alternative Names
AChR
UniProt
P02708 (For the alpha-subunit)
Immunogen
Human muscle AChR.
Application Notes
This antibody binds to the human muscle Acetylcholine receptor, which is a ligand- gated ion channel, transducing an action potential into the muscle cells. The antibody binds to the main immunogenic region (MIR) and prevents ligand-binding.
Antibody First Published
Kontou et al. Characterisation, crystallisation and preliminary X-ray diffraction analysis of a Fab fragment of a rat monoclonal antibody with very high affinity for the human muscle acetylcholine receptor. FEBS Letters 1996; 389(2):195-198 PMID:8766828
Note on publication
Describes the generation of a super-high-affinity rat antibody against human muscle AChR and subsequent crystallography.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
