Cat. No.
MABL-2081
Application
Block, FC
Isotype
Engineer antibody
Species Reactivity
Rat
Clone No.
OX-81
From
Recombinant Antibody
Specificity
OX-81 binds specifically to IL-4. IL-4 is a globular signalling protein which is involved in the stimilation of activated B and T cell proliferation and the differentiation of B cells into plasma cells. IL-4 also regulates B cell class switching to IgE, upregulates MHC class II expression and plays a role in the inflammation response and wound repair.
Alternative Names
BSF-1; OX81; MRC OX-81; MRC OX81; interleukin 4; interleukin-4; IL4; B- cell IGG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; BSF1; Lymphocyte stimulatory factor 1
UniProt
P20096
Immunogen
OX-81 was prepared by immunizing BALB/c mice with full-length IL-4.
Application Notes
OX-81 can be used to neutralise the effects produced by IL-4 and for FC studies.
Antibody First Published
Mason et al.Prevention of experimental allergic encephalomyelitis in rats by targeting autoantigen to B cells: evidencethat the protective mechanism depends on changes in the cytokine response and migratory properties of theautoantigen-specific T cells. J Exp Med. 1995 Aug 1;182(2):335-44. PMID:7543135
Note on publication
Describes the use of OX-81 in identifying the role of IL-4 in preventing EAE (experimental allergic encephalomyelitis) induction by anti-IgD-peptide pretreatment. Pretreatment with OX60-pep prevented the development of EAE it was observed that injection
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
