Cat. No.
MABL-2275
Application
ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
AbAb01LOX1
From
Recombinant Antibody
Specificity
This antibody binds oxidized low density lipoprotein (ox-LDL), which is a receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis.
Alternative Names
LOX1; hLOX-1; OLR1; CLEC8A; Oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; C-type lectin domain family 8 member A; Lectin-like oxidized LDL receptor 1; Lectin- like oxLDL receptor 1; Lectin-type oxidized LDL receptor 1; Oxidized low-density lipoprotein receptor 1 soluble form
UniProt
P78380
Immunogen
The original antibody was isolated from a human scFv phage display library by panning against human Lox-1.
Application Notes
This antibody can be used for the detection of Lox-1, which is a marker for early diagnosis of atherosclerosis. The binding characterization of this antibody was done using ELISA. The binding affinity of this antibody for human Lox-1 was determined using Bio-layer Interferometry (BLI) and it was reported that the binding affinity of this scFv antibody was Kd= 6.69 nM (CN107216390).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
