Cat. No.
MABL-2342
Application
Blocking, ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
LEM-2/15
From
Recombinant Antibody
Specificity
This antibody binds to residues 218-233 of the V-B loop of MT1-MMP with a Kd of 2.32E10-9M.
Alternative Names
MT1-MMP
UniProt
Immunogen
The cyclic peptide possessing the sequence of residues 218-233 of the V-B-loop of MT1-MMP.
Application Notes
This antibody binds to residues 218-233 of the V-B loop of MT1-MMP which is a mediator of cell migration and is frequently involved in malignancy of tumours by promoting metastasis.The antibody acts as a non-competitive inhibitor of the receptor.
Antibody First Published
Udi et al. 2015 Inhibition mechanisms of membrane metalloprotease by an exosite swiveling conformational antibody. Structure 2015; 23: 104-115 PMID:25482542
Note on publication
Describes the crystal structures of the LEM-2/15 bound to MT1-MMP.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
