Key features and details | |
Cat. No. | MABL-982 |
Name | Anti-CD45 mAbs |
Clone No. | AFD- YTH54.12 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Depletion, IP, FC, IF |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds human CD45, the leukocyte common antigen, at epitope Q2. |
Alternative Name | PTPRC; leukocyte common antigen; LCA;CD45; Receptor-type tyrosine- protein phosphatase C; Leukocyte common antigen; L-CA; Itgb2; Lymphocyte antigen 5; Ly-5; T200; protein tyrosine phosphatase receptor type C |
UniProt | P08575 |
Immunogen | Human T-cells injected into DA rats. |
Application Notes | This antibody binds to and immunoprecipiates human CD45. In the original rat IgG2b format it was shown to trigger complement mediated lysis and synergizes with clone YTH24.5 (Ab00671) which binds a different epitope on human CD45. |
Antibody First Published | Bidon et al. Therapeutic potential of monoclonal antibodies to the leukocyte- common antigen. Synergy and interference in complement-mediated lysis Transplantation. 1985 Nov;40(5):538-44. PMID:2414870 |
Note on publication | Describes generation and characterization of the synergistic effect of several anti- CD45 antibodies on lysis. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
