Cat. No.
MABL-2405
Application
WB, ELISA, IHC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
ABM58060-20A2-PU
From
Recombinant Antibody
Specificity
This antibody binds human DNA mismatch repair protein MSH6. MSH6 forms a heterodimer with MSH2 to make the human MutSα mismatch repair complex and initiates DNA repair. The DNA mismatch repair system (MMR) is composed of enzyme molecules that specifically repair DNA base mismatches. Defects in expression of MSH6 are often associated with hereditary non-polypatopathic colorectal cancer (HNPCC).
Alternative Names
hMSH6; p160; GTBP; GTMBP; DNA mismatch repair protein Msh6; G/T mismatch-binding protein; MutS protein homolog 6; MutS-alpha 160 kDa subunitC; GMCC NO.17492; 44
UniProt
P52701
Immunogen
The original antibody was generated by immunizing BALB/c mice with recombinant human MSH6 protein.
Application Notes
The binding specificity of this antibody for human MSH6 was determined using ELISA. This antibody was capable of detecting recombinant MSH6 in a western blot. This antibody was also used in the immunohistochemical analysis of colon cancer, bladder cancer and testicular tissues. This antibody shows similar staining of MSH6 protein compared to the commercially available antibody 44 (CN111454365).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
