Cat. No.
MABL-2425
Application
in vitro, in vivo
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
MuSK #13
From
Recombinant Antibody
Specificity
This antibody is specific for human MuSK.
Alternative Names
Muscle-specific kinase receptor; Muscle, skeletal receptor tyrosine- protein kinase; Muscle-specific tyrosine-protein kinase receptor
UniProt
O15146
Immunogen
This antibody was raised by immunizing mice with human MuSK.
Application Notes
The original antibody was used in vitro to test if it could activate its target. It showed to be a potent MuSK activator. The antibody was also tested in vivo on mice. Here is was shown to localize to the neuromuscular junctions here it increased innervation. This antibody did not show any delay in onset of ALS symptoms (Sengupta-Ghosh et al., 2019; PMID: 30528255).
Antibody First Published
Sengupta-Ghosh et al. Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS Neurobiol Dis. 2019 Apr:124:340-352. PMID:30528255
Note on publication
In the original paper they treated the SOD1G93A mouse model of ALS with an agonist antibody to muscle specific kinase (MuSK), a receptor tyrosine kinase required for the formation and maintenance of the neuromuscular junction.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
