Cat. No.
MABL-2482
Application
ELISA, FC
Isotype
Engineer antibody
Species Reactivity
cynomolgous monkey, Human, Mouse
Clone No.
ADI-27744 (A44)
From
Recombinant Antibody
Specificity
This antibody recognizes binds human and cynomolgous monkey NKG2D with similar affinity and shows low binding affinity for mouse NKG2D. Natural killer (NK) cells serve as key innate effectors and their activity has been considered a prognostic biomarker in diverse human diseases. NKG2d functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. It provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. I also acts as a costimulatory receptor for T-cell receptor (TCR) in CD8+ T-cell-mediated adaptive immune responses by amplifying T-cell activation. and participates in NK cell-mediated bone marrow graft rejection.
Alternative Names
KLRK1; CD314; NKG2-D type II integral membrane protein; NK cell receptor D; Killer cell lectin-like receptor subfamily K member 1; NKG2-D-activating NK receptor; KYK2; KYK- 2.0
UniProt
P26718
Immunogen
Application Notes
This antibody is recommeded for detection of human, cynomolgous monkey and mouse NKG2D by ELISA. This antibody was capable of recognizing EL4 mouse lymphoma cell lines expressing human or mouse NKG2D-CD3 zeta signaling domain chimeric antigen receptors in a flow cytometry assay (US20210079102).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
