Cat. No.
MABL-2817
Application
crystallography, SPR
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
BCD090-M2
From
Recombinant Antibody
Specificity
BCD090-M2 recognises erbB3, a receptor tyrosine kinase. The overexpression of erbB3 in breast cancers is associated with reduced survival in patients.
Alternative Names
HER3; Proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; erbB3
UniProt
P21860
Immunogen
The sdAb was selected from a Llama-derived phage antibody library.
Application Notes
The crystal structure of BCD090-M2 has been obtained (Eliseev et al, 2018). SPR indicates the equilibrium dissociation constant for BCD090-M2 bound to immobilised erbB3 is 1 μm (Eliseev et al, 2018).
Antibody First Published
Eliseev et al, 2018. Crystal structures of a llama VHH antibody BCD090-M2 targeting human ErbB3 receptor F1000Research 2018, 7:57
Note on publication
Describes the purification of BCD090-M2 from the phage antibody library and its characterisation through SPR and crystallography.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
