Cat. No.
MABL-3053
Application
dotblot, ITC, XRC, ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
tAb2
From
Recombinant Antibody
Specificity
tAb2 binds the N-terminal sequence of transforming growth factor alpha, VVSHFND (with residues 4 to 7 being the minimal binding epitope).
Alternative Names
TGFA, Transforming growth factor A
UniProt
P01135
Immunogen
Biologically active hemocyanin-coupled human TGFalpha.
Application Notes
Human transforming growth factora (TGFa) consists of 50 amino acid residues with three disulphide bridges. It belongs to the family of epidermal growth factor related peptides and binds to EGFreceptor. It is involved in cell proliferation in healthy cells and is found in various cancer cells. Transfection of Fibroblasts with the TGFa gene induces tumor formation.
Antibody First Published
Hoeprich PD Jr Identification of Immunodominant Regions of Transforming Growth Factor alpha J Biol Chem. 1989 Nov 15;264(32):19086-91.2478554
Note on publication
Describes the generation of various anti-TGFalpha antibodies and characterisation of their epitopes and binding affinitites.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
