Cat. No.
MABL-3088
Application
ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
L3C
From
Recombinant Antibody
Specificity
This antibody binds human TIM-3. Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein expressed on the cell surface of IFNγ producing CD4+ Th1 and CD8+ Tc1 cells. This protein is also expressed on the surface of Th17 cells, regulatory T-cells and innate immune cells like dendritic cells, NK cells and monocytes. It is a cell surface receptor implicated in modulating innate and adaptive immune responses.
Alternative Names
CD366; HAVCR2; HAVcr-2; TIM3; TIMD-3; TIMD3; Hepatitis A virus cellular receptor 2; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3
UniProt
Q8TDQ0
Immunogen
The original antibody was generated by immunizing Balb/c mice with human TIM-3.
Application Notes
This antibody can be used in the detection of human TIM-3 from plasma of patients using sandwich ELISA. The recombinant human rhGal-9 protein was used to capture TIM-3 and this antibody was used as a detecting antibody. The detection sensitivity of this antibody for TIM-3 was 1ng/ml (CN103665164).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
