Key features and details | |
Cat. No. | MABL-1076 |
Name | Anti-CD7 mAbs |
Clone No. | AFD- RFT2 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | FC, IF |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds human CD7. CD7 is expressed on the majority of immature and mature T- lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. CD7 is useful in the identification of precursor T cells as well as an important marker for the identification of leukemic T cells. |
Alternative Name | GP40; TP41; T-cell antigen CD7; T-cell leukemia antigen; T-cell surface antigen Leu-9 |
UniProt | P09564 |
Immunogen | |
Application Notes | This antibody binds human T cell antigen CD7 and can be used for the detection of CD7 on cell surfaces using flow cytometry. This antibody can also be used for the study of CD7 expression on cells of T cell lineage using double and triple immunofluorescence assays (PMID: 2479683). The chimeric version of this antibody has been studied as a prophylactic regimen in renal allograft patients. The antibody was well tolerated, induced a modulation of the CD7 molecule, and did not trigger anti-mAb host antibodies (PMID: 2479683). This antibody was used in the treatment of patients with rheumatoid arthritis. During treatment T-lymphocyte numbers decreased and T-lymphocyte CD7 expression was absent in all but one patient (PMID: 1720991). This antibody shows potent immunosuppressive effects in vitro. |
Antibody First Published | Hienrich et al. Characterization of a human T cell-specific chimeric antibody (CD7) with human constant and mouse variable regions. J Immunol. 1989 Dec 1;143(11):3589-97. PMID:2479683 |
Note on publication | Describes the generation of a chimeric antibody against human T cell-specific CD7 antigen. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
