Anti-CD72 mAbs

Cat. No.

MABL-1097

Name

Anti-CD72 mAbs

Clone No.

AFD- BU40

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Activate, stimulatory, FC

Species Reactivity

Human

Basic Information

Specificity

This antibody is specific for CD72, which is   highly expressed by pre-B cells and B-cells, but not terminally   differentiated plasma cells.

Alternative Name

Lyb-2; B-cell differentiation antigen CD72

UniProt

P21854

Immunogen

This antibody was raised against the HF B1   plasmacytoid cell line, which is considered to be late B-like.

Application Notes

This antibody has been used to investigate   cell-surface expression of CD72 in FACS analysis (Kataoka et al, 2013). This   antibody has been shown to induce resting B cells to enter the G1 phase of   the cell cycle, stimulate B cell expression of major histocompatibility   complex class II antigen and potentiate the capacity of IL-4 to induce CD23   production (Katira et al, 1992). It also stimulates TNF-α and IL-6 production   in CD14+ monocytes (Yoshida et al, 2015). Ligation of CD72 by this antibody   has been observed to suppress the proliferation of an acute myelogenous   leukaemia cell line (Kataoka et al, 2013).

Antibody First Published

Van de Velde et al. The B-cell surface   protein CD72/Lyb-2 is the ligand for CD5. Nature. 1991 Jun   20;351(6328):662-5. PMID:1711157

Note on publication

Describes the use of this antibody to block   the CD5-CD72 interaction

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.