Key features and details | |
Cat. No. | MABL-1109 |
Name | Anti-CD79b mAbs |
Clone No. | AFD- AT105-1 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | functional assay, WB |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody specific for the extracellular domain of human CD79b human CD79b. CD79b is required in tandem with CD79A for initiation of the signal transduction cascade induced by the B-cell antigen receptor complex which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. |
Alternative Name | B-cell antigen receptor complex-associated protein beta chain; CD79B; B- cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein |
UniProt | |
Immunogen | The mouse version of this antibody was raised by immunizing a mouse with the extracellular domain of CD79B. |
Application Notes | Expression of CD79b in Raji, Daudi, and EHRB B-cell lines and the EHRB transfectant clones 9 and 12 was determined with a western blot using the mouse version of this antibody (Cragg et al, 2002; pmid:12384401). To stimulate HEK293 cells transfected with a AttBR4 site during a SHIP-1 recruitment assay the mouse version of this antibody was used. The antibody did manage to increase folding is some situations (Stopforth et al, 2018; pmid:29351998). To further our understanding of CLL biology, a western blot was performed on lysed isolated B-cells and CLL cells using the mouse version of this antibody (Johnston et al, 2018; pmid:29367434). |
Antibody First Published | Cragg et al. The alternative transcript of CD79b is overexpressed in B-CLL and inhibits signaling for apoptosis Blood. 2002 Nov 1;100(9):3068-76. PMID:12384401 |
Note on publication | The expression of DeltaCD79b in B-CLL and other lymphoid malignancies was assesed and its function was investigated. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
