Key features and details | |
Cat. No. | MABL-1151 |
Name | Anti-CD8a mAbs |
Clone No. | AFD- YTC 141.1HL |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | FC, IHC |
Species Reactivity | Green monkey, Human, Cynomolgus Monkey |
Basic Information | |
Specificity | This antibody recognises human CD8. CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). CD8 is a T-cell co-receptor involved in the recognition ofMHC class I molecules. It is present on cytotoxic/suppressor T lymphocytes. |
Alternative Name | Leu2; CD8; CD8A; T-cell surface glycoprotein CD8 alpha chain; T- lymphocyte differentiation antigen T8/Leu-2; CD8a; p32 |
UniProt | P01732 |
Immunogen | This antibody was raised against mouse L cells transfected with human CD8 gene as immunogen. |
Application Notes | YTC 141.1HL antibody is recommended for the immunohistochemical and flow cytometric identification and analysis of CD8-positive cells. For instance, this antibody was used to immunohistochemically stain skin sections to investigate the composition of the inflammatory infiltrate perfusing the tissue (Yawalkar et al., 2000). Finally, YTC 141.1HL synergistic with Ab01039. |
Antibody First Published | Yawalkar et al. Infiltration of cytotoxic T cells in drug-induced cutaneous eruptions. Clin Exp Allergy. 2000 Jun;30(6)：847-55. PMID：10848903 |
Note on publication | This article describes an early application of this antibody to IHC. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
