Anti-CD96 mAbs

Cat. No.

MABL-1159

Name

Anti-CD96 mAbs

Clone No.

AFD- 6A6

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Blocking, FC

Species Reactivity

Mouse

Basic Information

Specificity

 This antibody is specific for murine CD96,   and recognises an epitope in the first Ig domain.

Alternative Name

 TACTILE; T-cell surface protein tactile; T   cell-activated increased late expression protein

UniProt

 Q3U0X8

Immunogen

 This antibody was raised by immunising rats   with murine CD96.

Application Notes

This antibody blocks murine CD96-CD155   interaction, and has been shown to bind to the first Ig domain of CD96 and   compete with CD155 binding (Roman Aguilera et al, 2018). This antibody   displays significant anti-metastatic activity in four experimental lung   metastases models and one spontaneous tumour metastasis model (Roman Aguilera   et al, 2018), with a potency greater than the anti- CD96 monoclonal   antibodies 3.3 and 8B10. The binding specificity of this antibody has been   determined in flow cytometric analysis of HEK-293 cells transfected with a   range of CD96 Ig domain chimeric constructs (Roman Aguilera et al, 2018).

Antibody First Published

Seth et al. The murine pan T cell marker   CD96 is an adhesion receptor for CD155 and nectin-1. Biochem Biophys Res   Commun. 2007 Dec 28;364(4):959-65. PMID:17971293

Note on publication

Describes the original generation of this   antibody, and its characterisation.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.