Key features and details | |
Cat. No. | MABL-1220 |
Name | Anti-Claudin-18.2 mAbs |
Clone No. | AFD- 2C6.9 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | functional assay |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody is specific for human claudin-18.2. Alterations in claudin expression can impair tight junction function, influence signaling pathways, and act as a tumor-promoting event in some epithelial cancers. Claudin 18.2 is overexpressed in various tumor type and is found to be a potentially important target in advanced gastric cancer. |
Alternative Name | CLDN18.2; C18-23-3G-1E1 |
UniProt | P56856 |
Immunogen | |
Application Notes | This antibody can be used for the detection of human claudin 18.2. This antibody was also used in the generation of a CAR-T cell receptor. CLDN18.2 CAR-T specifically binds to tumor cells, activated 2C6.9-T-PD-1 CAR-T alleviates or eliminates immunosuppression by secreting anti-PD-1 antibodies, increasing the anti-tumor effect. 2C6.9-T can activate primary T cells and efficiently mediate the killing of tumor cells expressing CLDN18.2 by T cells and caused a significant increase in cytokine secretion (CN113754780). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
