Key features and details | |
Cat. No. | MABL-1221 |
Name | Anti-Claudin-18.2 mAbs |
Clone No. | AFD- CLDN18.2-v.19 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | FC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody is specific for human claudin-18.2 with no cross reactivity with claudin 18.1. Alterations in claudin expression can impair tight junction function, influence signaling pathways, and act as a tumor-promoting event in some epithelial cancers. Claudin 18.2 is overexpressed in various tumor type and is found to be a potentially important target in advanced gastric cancer. |
Alternative Name | CLDN18.2; 2C6.9-HZ21; HuCLDN18.2-v. 19; CLDN18.2 v. 19 |
UniProt | P56856 |
Immunogen | The original antibody was generated by grafting CDRs of the parental mouse antibody onto human framework regions. |
Application Notes | The binding specificity of this antibody to human Claudin 18.2 expressed on the surface of HEK293 cells and Kato III cells was done using flow cytometry. The in-vivo anti-tumor activity of this antibody was evaluated in a syngeneic Mc38-huCLDN18.2 xenograft model in mice, which is a murine claudin18.2-/-mouse colon cancer cell line that has been engineered to expresses human claudin 18.2 (WO2021047599). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
