Key features and details | |
Cat. No. | MABL-1222 |
Name | Anti-Claudin-18.2 mAbs |
Clone No. | AFD- E1 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | FC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody is specific for human claudin-18.2 and does not cross react with claudin-18.1. Alterations in claudin expression can impair tight junction function, influence signaling pathways, and act as a tumor-promoting event in some epithelial cancers. Claudin 18.2 is overexpressed in various tumor type and is found to be a potentially important target in advanced gastric cancer. |
Alternative Name | CLDN18.2; C18-23-3G-1E1 |
UniProt | P56856 |
Immunogen | The original antibody was generated by immunizing mice with CHO cells stably transfected with human claudin-18.2. |
Application Notes | The binding of this antibody to claudin-18.2 expressed on the surface of CHO cells was determined using flow cytometry (CN113321730). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
