Anti-CXCR3 mAbs

Cat. No.

MABL-1305

Name

Anti-CXCR3 mAbs

Clone No.

AFD- V44D7

From

Recombinant Antibody

Isotype

Engineer antibody

Application

inhibit, ELISA, FC

Species Reactivity

Human

Basic Information

Specificity

This antibody binds human CXCR3. This protein acts as a receptor for C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human   mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway.   Isoform 2 human mediates the proliferation, survival and angiogenic activity   of microvascular endothelial cells (HMVEC) through a cAMP- mediated signaling   pathway. Some of the disorders associated with CXCR3 signaling include   diabetes mellitus type 1 and psoriasis.

Alternative Name

CD183; CXC-R3; CXCR-3; CKR-L2; IP-10   receptor; GPR9; C-X-C chemokine receptor type 3; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor

UniProt

P49682

Immunogen

The original antibody was generated by immunizing   BALB/c mice with CXCR-3 expressing NSO cells. The humanized version of the   antibody was created by grafting CDRs of the original murine antibody onto   human framework regions.

Application Notes

The binding characterization of this   antibody to human CXCR3 was done using competitive ELISA. This antibody is   capable of inhibiting binding of 125I-labeled IP-10 and -I-Tac to primary Th1   cells. This antibody can be used for the study of expression of CXCR3 on the   surface of Th1 cells using flow cytometry. This antibody also inhibited Th1   cell migration mediated by CXCR3 chemokines (US8435522).

Antibody First Published

Note on publication

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.