Key features and details | |
Cat. No. | MABL-1307 |
Name | Anti-CXCR4 mAbs |
Clone No. | AFD- 281F12 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA, FC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody is specific for CXCR4. |
Alternative Name | CXC-R4; CXCR-4; C-X-C chemokine receptor type 4; fusin; CD184; 2S201E; FB22; HM89; HSY3RR; LAP-3; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM; WHIMS; WHIMS1; Leukocyte-derived seven transmembrane domain receptor |
UniProt | P61073 |
Immunogen | |
Application Notes | The binding of the original version of this antibody (VHH) to CXCR4-expressing viral lipoparticles was characterized in an ELISA. Furthermore, it was analyzed for its ability to compete with the ligand CXCL12 (or SDF-1a) for receptor binding by displacement of biotinylated SDF-1 on Caki-CXCR4 cells in flow cytometry. This antibody exhibited medium/low potency (IC50 ≥ 10 nM). In its bi-specific construction with clone 57A07, it served a functional role (US20220242958). |
Antibody First Published | |
Note on publication | The original publication describes the construction and characterization of various bi- specific antibodies. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
