Key features and details | |
Cat. No. | MABL-1312 |
Name | Anti-Cyclobutane pyrimidine dimer mAbs |
Clone No. | AFD- C3B6 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA |
Species Reactivity | Species independent |
Basic Information | |
Specificity | This antibody recognizes UV-irradiated polynucleotides and oligonucleotides that contain the (6–4)-dipyrimidine photoproduct. |
Alternative Name | CPD |
UniProt | |
Immunogen | The original antibody was generated by hyperimmunizing mice with UV irradiated polydeoxynucleotides. |
Application Notes | This antibody is recommended for detection of DNA damage caused by UV irradiation. This antibody is also known as αUVssDNA-1. Recombinant C3B6 scFv binds UV-poly(dT) in an ELISA with no evidence of cross-reactivity with unirradiated polythymidylic acid [poly(dT)](PMID: 10710441). |
Antibody First Published | Strickland et al. Characterisation of two monoclonal antibodies specific for dimerised and non-dimerised adjacent thymidines in single stranded DNA. Photochem Photobiol. (1981); 34(5):595-601. PMID: 7301937 |
Note on publication | Describes the generation of of two antibodies, one recognizing the thymidine dimers and other that recognizes the unirradiated or UV-irradiated tracts of thymidine. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
