Anti-DCIR mAbs

Cat. No.

MABL-1362

Name

Anti-DCIR mAbs

Clone No.

AFD- 9E 8

From

Recombinant Antibody

Isotype

Engineer antibody

Application

FC

Species Reactivity

Human

Basic Information

Specificity

This antibody is specific for human DCIR,   which is expressed by monocytes, B cells, neutrophils, granulocytes and   dendritic cells.

Alternative Name

CD367; Clec4A; C-type lectin domain family 4   member A; LLIR; CLECSF6; C-type lectin DDB27; C-type lectin superfamily member 6; Dendritic cell immunoreceptor; Lectin-like immunoreceptor

UniProt

Q9UMR7

Immunogen

This antibody was raised by immunising BALB/c   mice with a dendritic cell immunoreceptor ectodomain-human Fc fusion protein.

Application Notes

This antibody has been used in flow   cytometric analysis of DCIR expression by peripheral blood mononuclear cells   (Klechevsky et al, 2010). A recombinant humanised form of this antibody fused   to protein antigens is under investigation as an antigen-targeting vaccine   (Flamar et al, 2012), and has been shown to trigger antigen-specific CD8+ T   cell immunity.

Antibody First Published

Klechevsky et al. Cross-priming CD8+ T cells   by targeting antigens to human dendritic cells through DCIR Blood. 2010 Sep 9; 116(10): 1685–1697.

Note on publication

Describes the original generation of this antibody,and preliminary investigation into its use as an antigen-targeting vaccine.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.