Key features and details | |
Cat. No. | MABL-1383 |
Name | Anti-Digoxigenin mAbs |
Clone No. | AFD- 19-11 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA |
Species Reactivity | Species independent |
Basic Information | |
Specificity | This antibody is specific for digoxigenin A. Digoxigenin (DIG) is a hydroxy steroid that consists of 5beta-cardanolide, found exclusively in the flowers and leaves of the plants Digitalis purpurea, Digitalis orientalis and Digitalis lanata. It is a hapten, a small molecule with high antigenicity, that is used in many molecular biology applications. |
Alternative Name | Digoxigenin; DOG; DIG; ChEBI: 42098; CAS:1672-46-4 |
UniProt | |
Immunogen | The original antibody was generated by immunizing mice with digoxin conjugated to human serum albumin. |
Application Notes | This antibody can be used for the detection of digoxigenin via ELISA. This antibody was also used for the generation of bispecific antibodies that bind cell-surface targets as well as digoxigenin (Dig) for targeted payload delivery (PMID: 21536919). |
Antibody First Published | Metz et al. Bispecific digoxigenin-binding antibodies for targeted payload delivery. Proc Natl Acad Sci U S A. 2011 May 17; 108(20): 8194–8199. PMID: 21536919 |
Note on publication | Describes the generation of bispecific antibodies for targeted payload delivery. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
