Key features and details | |
Cat. No. | MABL-1555 |
Name | Anti-Factor VIII mAbs |
Clone No. | AFD- YK3.3.38 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody is specific for an epitope 'RPLYSRRLPKGVKHLKDFPILPGEI' (residues 389 to 510) in the A2 domain of the human factor VIII, a glycoprotein involved in blood coagulation. Factor VIII acts as a cofactor for factor IXa which converts factor X to the activated form Xa in the presence of calcium and phospholipids. Defects in the F8 gene, which encodes Factor VIII, result in the coagulation disorder hemophilia A. |
Alternative Name | AHF; FVIII; Factor 8; anti-hemophilic factor; Coagulation factor VIII; procoagulant component |
UniProt | P00451 |
Immunogen | The original antibody was isolated from a scFv phage display library generated using the peripheral blood lymphocytes from a hemophilia patient. |
Application Notes | This antibody can bind human blood coagulation factor VIII in an ELISA. It was reported that this antibody potently inhibits the coagulation activity of factor VIII in vitro at a concentration of 10 ng/ml. This antibody does not inactivate FVIII bound with vWF but inactivated FVIII free from vWF (US20040120951). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
