Key features and details | |
Cat. No. | MABL-1556 |
Name | Anti-Factor VIII A2 domain mAbs |
Clone No. | AFD- BOIIB2 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | inhibit, ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds the A2 domain of the human factor VIII, a glycoprotein involved in blood coagulation. Factor VIII acts as a cofactor for factor IXa which converts factor X to the activated form Xa in the presence of calcium and phospholipids. Defects in the F8 gene, which encodes Factor VIII, result in the coagulation disorder hemophilia A. |
Alternative Name | AHF; FVIII; A2 domain; Factor 8; anti-hemophilic factor; Coagulation factor VIII; procoagulant component |
UniProt | P00451 |
Immunogen | The original antibody was generated from the peripheral blood lymphocytes obtained from a hemophilia patient. |
Application Notes | The binding specificity and epitope characterization of this antibody was determined using ELISA. The ability of this antibody inhibit factor VIII function in vitro was studied using a chromogenic functional assay. It was reported that this antibody inhibited the conversion of factor X to factor Xa at concentration of 0.1 μg/ml. It was found that this antibody inhibits thrombin production using both the intrinsic and extrinsic pathway of coagulation (US20080206254). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
