Key features and details | |
Cat. No. | MABL-1593 |
Name | Anti-Fibronectin mAbs |
Clone No. | AFD- A2 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Biacore, WB, ELISA, IHC-Fr |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds to the ED-B domain of human fibronectin. |
Alternative Name | FN; EDB(+) FN; ED-B domain of fibronectin; Extra domain-B containing fibronectin |
UniProt | P02751 |
Immunogen | 2D-PAGE gel isolated human Extra-Domain containing fibronectin from lysate of human melanoma COLO-38 cells. |
Application Notes | Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Extra domain-B containing fibronectin has been proposed marker of angiogenesis, has been shown to be expressed in a number of human cancers and in ocular neovascularization in patients with proliferative diabetic retinopathy. |
Antibody First Published | Pini et al. Design and use of a phage display library. Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel. J Biol Chem.1998 Aug 21;273(34):21769-76. PMID:9705314 |
Note on publication | Describes generation, using phage display, of antibodies with subnanomolar affinity against markers of angiogenesis. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
