Key features and details | |
Cat. No. | MABL-1720 |
Name | Anti-Glycoprotein Ilb/IIIa mAbs |
Clone No. | AFD- SE |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | FC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds the glycoprotein GPIIb/IIIa complex (CD41/CD61 complex). The GPIIb/IIIa is a heterodimeric complex formed after synthesis of one lib and one Ilia subunit. The principal ligand for GPIIb/IIIa is fibrinogen, but it also binds to fibronectin, von Willebrand factor, vitronectin, thrombospondin and CD40 ligand. The binding between GPIIb/IIIa and fibrinogen dimers leads to platelet aggregation and thrombus formation, and this is possible only when the receptor adopts its activated conformation. |
Alternative Name | GPIIb/IIIa; CD41/CD61; integrin allb83 |
UniProt | P08514 |
Immunogen | The original antibody was generated by screening human scFv antibody libraries. |
Application Notes | The antibody bound to activated platelets and inhibited platelet activation. This antibody was used for detection of activated platelets by flow cytometry (WO2020237304). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
