Anti-Glycosylated TIGIT mAbs

Cat. No.

MABL-1721

Name

Anti-Glycosylated TIGIT mAbs

Clone No.

AFD- Ab01TIGIT

From

Recombinant Antibody

Isotype

Engineer antibody

Application

WB, ELISA

Species Reactivity

Human

Basic Information

Specificity

This antibody binds the glycosylated form of the human TIGIT (T cell immunoreceptor with Ig and ITIM domains). TIGIT is a type I transmembrane protein that is a member of the CD28 family within the   Ig superfamily of proteins. It is an immune receptor present on some T cells   and natural killer cells (NK). It binds the poliovirus receptor (PVR) with   high affinity which causes increased secretion of IL10 and decreased   secretion of IL12B and suppresses T-cell activation by promoting the   generation of mature immunoregulatory dendritic cells.

Alternative Name

VSTM3; VSIG9; WUCAM; T-cell immunoreceptor   with Ig and ITIM domains; V-set and immunoglobulin domain-containing protein   9; V-set and transmembrane domain-containing protein 3; post translational   modification

UniProt

Q495A1

Immunogen

The original antibody was generated by   immunizing BALB/c mice with glycosylated human TIGIT protein.

Application Notes

The binding characterization of this antibody towards was done using ELISA.This antibody is also capable of recognizing  TIGIT expressed on CD8+ and CD4+ cell lysates in an western blot assay   (CN111705066).

Antibody First   Published

Note on publication

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.