Key features and details | |
Cat. No. | MABL-1854 |
Name | Anti-HLA-A2 mAbs |
Clone No. | AFD- UL-5 A1 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | FC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody recognizes a conformational epitope formed by the HLA-DR1 and the HLA-A2 peptide 'SDWRFLRGYHQYA' and binds to pMHC-II in a similar fashion as T cells. |
Alternative Name | HLA-A; Human leukocyte antigen A; HLA class I histocompatibility antigen; A-2 alpha chain; MHC class I antigen A-2 HLA-A; HLA class I histocompatibility antigen A-28 alpha chain; HLA class I histocompatibility antigen; A-28 alpha chain; MHC class I antigen A-28; HLA-DRA; HLA- DRA1; HLA class II histocompatibility antigen DR alpha chain; MHC class II antigen DRA; Fab-5 A1 |
UniProt | P01903; P04439 |
Immunogen | |
Application Notes | The specificity of this antibody to recognize peptide/MHC complex epitope on HLA- A2+, -DR1/DRB1*0101+ typed lymphoblast cell lines was tested using flow cytometry. This antibody can also recognize HLA-A2-,-DR1/DRB1*0101+ LCLs exogenously loaded with HLA-A2 peptides (105-117, 103- 117) (PMID: 9805656). |
Antibody First Published | Löffler et al. Recognition of HLA-DR1/DRB1*0101 molecules presenting HLA- A2 derived peptides by a human recombinant antibody, Fab-5 A1. Eur J Immunogenet. 1998 Oct;25(5):339-47. PMID:9805656 |
Note on publication | Describes the generation of a Fab version of an antibody which recognizes a conformational epitope formed by the HLA-DR1 and the HLA-A2 peptide. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
