Key features and details | |
Cat. No. | MABL-2035 |
Name | Anti-IL-17 mAbs |
Clone No. | AFD- MCAF5352A (Afasevikumab) |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | neutralize, SPR, Block, ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody is specific for human IL-17A and human IL-17F. It also binds their respective dimers — IL-17AA, IL-17AF, and IL-17FF. |
Alternative Name | IL17; IL-17A; IL17A; CTLA8; Interleukin-17A; IL-17A; Cytotoxic T- lymphocyte-associated antigen 8; CTLA-8; IL17F; IL-17F; Interleukin-17F; IL-17F; Cytokine ML-1; IL-17AA; IL- 17AF; IL-17FF |
UniProt | |
Immunogen | The original antibody was produced by immunizing HuMab® mice with human IL-17. |
Application Notes | This antibody successfully completed phase I clinical trials (Mitra et al., 2014; PMID: 25398489). The pharmacokinetics of this antibody and the post-dose levels of IL-17AA and IL-17FF in healthy were assessed as part of the phase I study (Peng et al., 2018; PMID: 30547287). The crystal structure of the Fab version of this antibody was resolved, and its binding kinetics (KD) was measured at 7.78 ± 0.23 pM. Furthermore, alterations to the antibody's aromatic residues in its binding site and their effect on binding kinetics were assessed (Tilegenova et al., 2020; PMID: 31779513). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
