Key features and details | |
Cat. No. | MABL-2103 |
Name | Anti-IL-6R mAbs |
Clone No. | AFD- AUK12-20 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | inhibit, ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds the human IL-6 receptor at a site that is different from the epitope recognized by Tocilizumab (PM-1). The presence of this antibody inhibits the binding of IL-6 to the human IL- 6R. |
Alternative Name | Interleukin-6 receptor subunit alpha; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1; Membrane glycoprotein 80; gp80; CD126 |
UniProt | P08887 |
Immunogen | The original antibody was generated by immunizing female BALB/c mice with 10.mu.g/mouse of the soluble IL-6R (SR 344) immunogen in Freund's complete adjuvant. |
Application Notes | This antibody can be used to inhibit the binding of IL-6 to its receptor IL-6R. It is also reported to inhibit IL-6 functions. The binding characterization of this antibody was done using ELISA (US5795965). This antibody was also reported to inhibit IL-6 dependent tumor cell growth (PMID: 8152440). This antibody was used in a study wherein the combined effect of antigrowth factor receptor antibodies was tested on growth limitation of myeloma cells (PMID: 8120920). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
