Key features and details | |
Cat. No. | MABL-2109 |
Name | Anti-IL-8 mAbs |
Clone No. | AFD- 928 (46G8) |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds human IL-8 and specifically recognizes an epitope containing amino acids sequence 'ELRCQCIKTYSK'. Interleukin-8 is a chemotactic factor that attracts neutrophils, basophils, and T- cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. |
Alternative Name | IL8; Interleukin-8; CXCL8; C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; T-cell chemotactic factor |
UniProt | P10145 |
Immunogen | The original antibody was generated by immunizing cohorts of XMG2 XENOMOUSE® transgenic mice with recombinant human Interleukin-8 (rhIL-8). |
Application Notes | This antibody binds human interleukin 8 with a very high affinity of Kd = 0.06 pM. The binding characterization of this antibody was done using ELISA (PMID: 16038881; US20140105905). |
Antibody First Published | Rathanaswami et al. Demonstration of an in vivo generated sub-picomolar affinity fully human monoclonal antibody to interleukin-8. Biochem Biophys Res Commun. 2005 Sep 9;334(4):1004-13. PMID:16038881 |
Note on publication | Describes the generation of an antibody with sub-picomolar affinity for human interleukin-8. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
