Anti-IL-9R mAbs

Cat. No.

MABL-2118

Name

Anti-IL-9R mAbs

Clone No.

AFD- AH9R2

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Blocking, IP

Species Reactivity

Human

Basic Information

Specificity

This antibody binds specifically to the   human IL-9 receptor alpha chain.

Alternative Name

Interleukin-9 receptor; IL9R; CD129

UniProt

Q01113

Immunogen

This antibody was raised by immunising DBA/2 mice with P815 mastocytoma cells transfected with human IL-9R cDNA.

Application Notes

This antibody has been used to   immunoprecipitate human IL-9R expressed by murine BW5147 cells transfected   with hIL-9R-encoding cDNA (Demoulin et al, 1996). This antibody binds to and   blocks the human IL-9Ra, and displays intermediate inhibitory activity; in a   TS1H9RA3 proliferation assay, half-maximal inhibition of 100 pg/ml human IL-9   requires 10 mg/ml of this antibody (de Smedt et al, 2000). Equally, treatment   with this antibody partially reduces the cellularity of human thymocytes in   chimeric human-mouse FTOC, with no effect on murine thymocytes (de Smedt et   al, 2000).

Antibody First   Published

Demoulin et al. A single tyrosine of the   interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic   activity, and growth regulation by IL-9. Mol Cell Biol. 1996   Sep;16(9):4710-6. PMID:8756628

Note on publication

Describes the original generation of this   antibody, and its use in immunoprecipitation analysis.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.