Anti-Integrin beta-7 mAbs

Cat. No.

MABL-2160

Name

Anti-Integrin beta-7 mAbs

Clone No.

AFD- FIB504

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Block, FC, IF

Species Reactivity

Human, Mouse

Basic Information

Specificity

FIB504 recognizes an epitope on intergin   beta-7 subunit that overlaps completely with the epitope defined by Fib27 and   Fib30, and also partially with the epitope defined by FIB21 and FIB22. In the   mouse beta-7 is selectively found on the majority of mature lymphocytes,   whereas a small subpopulation of thymocytes and bone marrow cells express   beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells.   Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion   and are involved in lymphocyte homing, leukocyte recruitment to inflammatory   sites, myogenesis, hemopoiesis, and melanoma metastasis.

Alternative Name

FIB-27; FIB 27; Fib-27; Fib27; Fib 27;   fib27; fib-27; fib 27; Integrin b7; integrin b-7; ITGB7; Gut homing receptor   beta subunit

UniProt

P26011

Immunogen

FIB504 was prepared by immunizing rats with   TK1 cells.

Application Notes

FIB504 can be used for IF, FC and can block   TKI cell aggregation and beta-7 intergrin- mediated cell adhesion.

Antibody First   Published

Andrew DP, et al. Distinct but overlapping   epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell   adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte   aggregation. J. Immunol. 153:3847 1994 PMID:7523506

Note on publication

Describes the use of FIB504 in defining   functional binding regions of alpha-4/beta-7 integrin by epitope mapping.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.