Anti-M-CSF mAbs

Cat. No.

MABL-2311

Name

Anti-M-CSF mAbs

Clone No.

AFD- RX1

From

Recombinant Antibody

Isotype

Engineer antibody

Application

neutralizing, SPR

Species Reactivity

Human, Mouse

Basic Information

Specificity

The antibody is specific for M-CSF. The   antibody binds to a linear epitope of M-CSF (amino acids 98-105).

Alternative Name

CSF-1; MCSF; PG-M-CSF; Lanimostim;   Macrophage colony-stimulating factor; Macrophage colony-stimulating factor 1;   Proteoglycan macrophage colony-stimulating factor

UniProt

P09603

Immunogen

Application Notes

The binding properties of the original format   of the antibody were analyzed using SPR analyses (Kd = 0.16 nM). The antibody   could neutralize human M-CSF activity, as measured by a proliferation assay   with M-NFS-60 cell line. Further, the Fab fragment of the antibody was able   to neutralize human M-CSF activity, but with less potency. The humanized   variant of the antibody was constructed (EP1913028B1).

Antibody First   Published

Note on publication

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.