Key features and details | |
Cat. No. | MABL-2351 |
Name | Anti-MET mAbs |
Clone No. | AFD-KY301-01 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Blocking, in vitro, in vivo, ELISA |
Species Reactivity | Cyno, Human, Mouse |
Basic Information | |
Specificity | This antibody is specific for human MET, but also binds MET from mice and cynomolgus monkeys. |
Alternative Name | SF receptor; HGF receptor; Proto-oncogene c-Met; Scatter factor receptor; Tyrosine-protein kinase Met; Hepatocyte growth factor receptor |
UniProt | P08581 |
Immunogen | The original antibody was raised by immunizing Alpaca with human MET antigen. |
Application Notes | The original antibody was used for an ELISA on human, mouse and monkey MET antigen. It showed binding to all of them. It was shown that this antibody is able to block HGF in vitro. The cytotoxicity of this antibody conjugated to MMAE was determined in vitro, it is shown that the antibody drug conjugate is cytotoxic to different tumor cell lines. This antibody was used in vivo on mouse with xenograft tumors made from HCT116 cells, it was shown to effectively inhibit tumor growth (CN117659203B). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
