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Anti-MHC I mAbs

简要描述:

This antibody is specific for murine MHC class I, and binds to polymorphic H-2 determinants expressed on most haplotypes. This antibody is, therefore, able to bind all H-2 class I molecules, independent of the allele. This antibody recognises a determinant distinct from those detected by most common mouse monoclonal anti-H-2 antibodies.

产品参数:

Cat. No.:MABL-2368

Species:Engineer

Species Reactivity:Mouse

Type:Recombinate

Application:IP, radioimmunoassay, IF

详细介绍

Key features and   details


Cat. No.

MABL-2368

Name

Anti-MHC I mAbs

Clone No.

AFD- R1-9.6

From

Recombinant Antibody

Isotype

Engineer antibody

Application

IP, radioimmunoassay, IF

Species Reactivity

Mouse

Basic Information


Specificity

This antibody is specific for murine MHC   class I, and binds to polymorphic H-2 determinants expressed on most   haplotypes. This antibody is, therefore, able to bind all H-2 class I  molecules, independent of the allele. This antibody recognises a determinant   distinct from those detected by most common mouse monoclonal anti-H-2   antibodies.

Alternative Name

R1.9.6; H-2; MHC-I; MHC Class I

UniProt


Immunogen

This antibody was raised by immunising Lewis   1F rats with mouse CH-1 lymphoma cells. Spleen cells from immunised rats were   fused with X-63Ag8-653 myeloma cells to generate hybridomas.

Application Notes

This antibody binds murine H-2 MHC class I molecules and has been used in both structural and biochemical studies. This antibody has been used in immunoprecipitation analysis (Robinson, 1987) and   in immunofluorescence assays for MHC-I surface expression (Karacsonyi et al.,   2004) and MHC-I endocytosis (Knorr et al., 2009). This antibody has also been employed to induce clustering of cell surface MHC-I in co-patching assays   (Knorr et al., 2009). Cellular radioimmune assays have been used to confirm   the binding of this antibody to spleen cells and assess its strain   specificity (Koch et al., 1983; PMID: 6192569).

Antibody First   Published

Koch et al Comparison of allogeneic and   xenogeneic determinants on the H- 2Kk molecule Transplantation, August 1983, Vol.36(2), pp.177-80 [Peer Reviewed Journal] PMID:6192569

Note on publication

Describes the original generation and   characterisation of this antibody.

COA Information For reference only, actual COA shall prevail

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


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