Key features and details | |
Cat. No. | MABL-2475 |
Name | Anti-Nicotinic acetylcholine alpha4 beta 2 receptor mAbs |
Clone No. | AFD- 12H2 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody recognizes human α4β2 receptor protein. The AChR responds by an extensive change in conformation after binding acetylcholine, that affects all subunits and leads to opening of an ion- conducting channel across the plasma membrane permeable to sodium ions. |
Alternative Name | CHRNB2; Nicotinic acetylcholine α4β2 receptor; Neuronal acetylcholine receptor subunit beta-2; human α4β2 nicotinic receptor; AChR |
UniProt | P17787 |
Immunogen | The original antibody was generated by immunizing female BALB/c mice with human α4β2 receptor protein purified in n-dodecyl-β-D-maltopyranoside (DDM). |
Application Notes | The binding characterization of this antibody to human α4β2 nicotinic receptor was done using ELISA. |
Antibody First Published | Walsh et al. Structural principles of distinct assemblies of the human α4β2 nicotinic receptor. Nature. 2018 May;557(7704):261-265. PMID:29720657 |
Note on publication | This paper investigates the structural basis of the distinctive biophysical and pharmacological properties of the two different stoichiometries of this receptor. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
