Key features and details | |
Cat. No. | MABL-2488 |
Name | Anti-NKp46 mAbs |
Clone No. | AFD- Bab281 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | IP, FC, IF |
Species Reactivity | Macaque, Human |
Basic Information | |
Specificity | The antibody is specific for human NKp46. The antibody cross-reacts with macaque NK46 but does not cross-react with mouse NKp46. NKp46 is a receptor expressed by NK cells. |
Alternative Name | Natural cytotoxicity triggering receptor 1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; Natural killer cell p46-related protein; NK-p46; hNKp46; CD335 |
UniProt | O76036 |
Immunogen | The original antibody was generated by immunizing Balb/c mice with recombinant human NKp46 protein. |
Application Notes | The antibody was used to immunoprecipitate NKp46 molecules from NK and COS-7 cells (Pessino et al., 1998; PMID 9730896 and Cantoni et al. 1999; PMID: 10049942). NK cells were analyzed for NKp46 surface expression by immunofluorescence and Flow Cytometry analysis using the antibody (Sivori et al., 1999; PMID: 10359120). The antibody binding to NKp46 promoted an increase of cytolytic activity in NK cells (Sivori et al., 1997; PMID: 9314561 and Sivori et al., 1999; PMID: 10359120). |
Antibody First Published | Sivori et al. p46, a novel natural killer cell-specific surface molecule that mediates cell activation J Exp Med. 1997 Oct 6;186(7):1129-36. PMID:9314561 |
Note on publication | The paper describes the generation and characterization of the antibody. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
