Key features and details | |
Cat. No. | MABL-2500 |
Name | Anti-Norovirus GII.4 mAbs |
Clone No. | AFD- 12A11 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA, blocking |
Species Reactivity | Norovirus |
Basic Information | |
Specificity | The antibody is specific for Norovirus GII.4. The antibody shows intra-genogroup cross- reactivity to genotypes 1, 3–7, 12, and 14 of genogroup II. |
Alternative Name | |
UniProt | |
Immunogen | A phage-displayed antibody library was generated from peripheral blood of healthy persons. The original antibody was isolated by screened using purified virus-like particles (VLPs) of strain Narita 104 (r104, genogroup II, genotype 4). |
Application Notes | The specificity of the original format of the antibody was confirmed by ELISA analysis. The blocking activity of the antibody against the interaction of homotypic VLPs with histo-blood group antigens were also assessed as an alternative to neutralization assay. The antibody showed a low blocking activity. |
Antibody First Published | Higo-Moriguchi et al. Isolation of cross-reactive human monoclonal antibodies that prevent binding of human noroviruses to histo-blood group antigens J Med Virol. 2014 Apr;86(4):558-67. PMID:24026909 |
Note on publication | The original paper identified a panel of human monoclonal antibodies targeting norovirus. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
