Key features and details | |
Cat. No. | MABL-2521 |
Name | Anti-NT-proBNP mAbs |
Clone No. | AFD- 1-10 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds NT-proB-type natriuretic peptide (NT-proBNP), a 76 amino acid cleaved N- terminal (NT)-pro hormone BNP (NT-proBNP), which is a non-active prohormone that is released from the protein proBNP. BNP is a naturally secreted cardiac regulatory hormone that influences blood pressure and vascular water retention in human physiology. The plasma BNP and NT-proBNP concentration are clinically recognized biomarkers for various cardiovascular diseases. |
Alternative Name | BNP; NT-pro-BNP; NT-proBNP(1-76); hBNP; NPPB; NT-proB-type natriuretic peptide; preproBNP; B-type natriuretic peptide; Natriuretic peptides B; Brain natriuretic factor prohormone; Brain natriuretic peptide; Gamma-brain natriuretic peptide; Iso-ANP |
UniProt | P16860 |
Immunogen | The original antibody was generated by introducing site directed mutations in CDRs of the parental mouse antibody. |
Application Notes | The original mouse IgG antibody binds human NT-proBNP with a binding affinity of Kd=1.6 X 10^(-10) M. This antibody can be used for the detection of NT-proBNP in a sample using ELISA (CN113004405). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
