Key features and details | |
Cat. No. | MABL-2571 |
Name | Anti-P-selectin mAbs |
Clone No. | AFD- PB1.3 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Blocking, functional assays, WB, ELISA, FC, IHC |
Species Reactivity | Human |
Basic Information | |
Specificity | PB1.3 recognizes human P-selectin. It reacts with human recombinant P-selectin and purified P- selectin, as well as with P-selectin on thrombin-activated platelets. In contrast, it does not cross-react with recombinant E- or L-selectin. P-selectin is a Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. |
Alternative Name | CD62P; CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein; PADGEM; MAb PB1.3 |
UniProt | P16109 |
Immunogen | The original mouse IgG1 version of this antibody was raised by immunizing RBF/DnJ mice with human platelets and purified human P-selectin. |
Application Notes | |
Antibody First Published | Mulligan et al. Neutrophil-dependent acute lung injury. Requirement for P- selectin (GMP-140) J Clin Invest. 1992 Oct;90(4):1600-7. doi: 10.1172/JCI116029. PMID:1383277 |
Note on publication | Describes the generation and characterization of the original mouse IgG1 version of PB1.3. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
